Man's Next Friend

Man's Next Friend

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Chinese scientists use CRISPR-Cas9 system to "edit" the genetic structure of Man's Best Friend to create a freakish mutant super dog.  Are humans next?

In October 2015 a team of Chinese scientists reported in Journal of Molecular Cell Biology that they were planning to genetically engineer a dog.  The dog, Canis familiaris, was selected for their experimentation because they

“...exhibit close similarities to humans in terms of metabolic, physiological, and anatomical characteristics, and thus are ideal genetic and clinical models to study human[s]...” 

Beagles were chosen for experimentation.

Researchers from the Key Laboratory of Regenerative Biology at the Guangzhou Institutes of Biomedicine and Health employed a ground breaking gene editing system known as CRISPR-Cas9 which stands for Clustered Regularly Interspaced Short Palindromic Repeats.  With CRISPR the researchers were able to locate and edit specific genes with extraordinary precision.  The CRISPR-Cas9 system also works fast and costs a fraction of older genetic engineering techniques.  

Their effort to modify the Beagle’s genetic structure was a success.  It was hailed as a major breakthrough in the field of genetics.  The Chinese scientists used the CRISPR-Cas9 gene editing system to precisely cleave or "knock-out" the gene called Myostatin (MSTN).  This gene is a

“negative regulator”

of

“skeletal muscle mass.” 

MSTN functions to make sure that too much muscle tissue does not develop.  Without the function of Myostatin, the rapid growth and regenerative capacity of muscle tissue would proceed unchecked.  This would lead to a condition in which an individual or animal becomes muscle bound and debilitated.  The Chinese scientists effectively the MSTN gene, allowing more muscle development without any apparent negative side effects.  The result was a dog with TWICE the muscle mass of a normal or “wild-type” dog

The dog with the most notable change, designated

“male puppy #11” 

was named

“Hercules.” 

Subsequent genetic testing of “male puppy #11” indicated that Hercules, in genetic terms, was

“a chimeric mutant dog.”

It’s naturally occurring “wild-type DNA” related to Myostatin was not present.  The Chinese researchers, using the CRISPR-Cas9 system, were able to completely replace this specific sequence of the dog’s natural DNA to create the mutation resulting in the extraordinary muscle mass.  

Genetic testing indicated that the muscle-enhancing genetic mutation of Hercules would propagate to the dog’s offspring.  Furthermore, the researchers discovered that

“the mutation can be transmitted to the next generation,...”

via natural mating habits of the mutant dog.  

The researchers expressed no desire to genetically engineer and then breed these super dogs for commercial purposes.  However, they acknowledged that others

“could move quickly to commercialize gene-altered dogs, potentially editing their DNA to change their size, enhance their intelligence...”

The choice of dogs for this kind of genetic experimentation is not by accident.  The decision to target and then modify the gene that regulates muscle mass is not coincidental.  According to David King, director of Human Genetics Alert, the success of the Chinese researchers to genetically alter dogs is

“...the first step to creating mutant children.”

For more than a century, the goal of eugenicists has been the creation of a “super” human. Eugenicist, racist, and Planned Parenthood Founder Margaret Sanger envisioned a genetically superior and racially pure

“...race of thoroughbreds.”

Margaret Sanger also believed that the

"unfit,"

"reckless breeders,"

"human weeds,"

and

"spawn that should never have been born"

should be eliminated via sterilization and

"birth control." 

Nazi German eugenicists pursued the creation of super men or

“Übermensch,”

The result was the targeted and systematic extermination of over six (6) millions Jews and other minorities the Nazis viewed as sub-human

“untermensch.” 

In add, more than 100 million people would die as a result of the Nazi German’s effort to achieve global domination through military conquest.  

Nazi scientist Dr. Josef Mengele (“The Angel of Death’), conducted horrific and brutal experimentation on Jewish children, mainly twins, in his effort to unlock the secrets of the human genome.  Today, in laboratories the world over, the CRISPR-Cas9 "gene editing" system enables scientists to manipulate the genetic structure of plants, animals, and even humans in ways that Mengele could never have imagined.  The pace at which CRISPR-Cas9 is being used, and the likelihood of unpredictable and uncontrolled genetic mutation, is so alarming that it’s inventor Jennifer Doudna urged her fellow scientists to refrain from experimentation with human embryos. 

Professor Doudna is a Molecular and Cellular biologist with the University of California, Berkeley.  She led the team that discovered the process by which simple bacteria defend themselves from viral attack.  She and her team duplicated the process that bacteria used to:

1) RNA to identify the DNA of the invading virus,

2) Cas protein molecule to “cut” and deactivate the invading DNA

3) Store copies of the invading DNA, and

4) Pass that immunity information to its progeny.

Her discovery is considered the biggest advance since the development of nuclear energy.  CRISPR-Cas9 is also considered to be, far and away, more dangerous. 

Professor Doudna was the first to call on her fellow scientists NOT to use CRISPR-Cas9 on human embryos.  Her call will be heeded.  

The Eugenics Age has begun.

Sources:

  1. Chinese scientists who made muscly ‘super dog’ could create genetically-modified human CHILDREN next’
  2. Generation of gene-target dogs using CRISPR/Cas9 system

  3. First Gene-Edited Dogs Reported in China

  4. Übermensch